The Sopranos

A doctor who runs the ER where James Gandolfini was taken before he was pronounced dead says there are no suspicious factors, such as alcohol, but the statement appears premature -- especially with respect to any drugs that might have been in the actor's system.

Professor Claudio Modini, the chief ER doc, says it looks like a heart attack, adding it was "probably a natural cause of death, myocardial infarction."

Gandolfini had acknowledged he had been addicted to cocaine and booze, and substance abuse played a part in his 2002 divorce.

As for the professor's tentative conclusion, it's premature to know if drugs or alcohol were a factor. It's also unclear what -- if any -- toxicology tests will be performed on Gandolfini's body.

As we previously reported, Gandolfini died Wednesday in Italy while on vacation with his son. He had been staying at the Boscolo Hotel Exedra in Rome (pictured below).

James Gandolfini's shocking death happened in the middle of a "guy's trip" for the actor and his teenage son, Michael ... TMZ has learned.

Multiple sources tell us James' trip was for pleasure and business -- first getting to spend some QT in Italy with Michael, who just recently graduated from the 8th grade ... and then attending the Taormina Film Festival in Sicily.

We're told Michael's mom -- James' first wife Marcy Wudarski -- immediately flew to Italy on Wednesday to be with her son ... after she was told James had died.

James and his son were very tight -- Michael is a big hockey fan, and he and his father were regulars at L.A. Kings home games.

James Gandolfini was in the market for a mysterious new ink job before his death -- dropping by an L.A. tattoo parlor earlier this month ... and promising to return with a special order.

TMZ has learned Gandolfini visited T-Man Tattoo in Studio City on June 1st -- and the owner (pictured above) tells us, the actor was extremely excited about a new tattoo he was planning.

Gandolfini didn't tell the owner what he wanted to get done -- but said he just moved to the neighborhood, and promised to return later this month for a full tat session.

The owner says Gandolfini was in great spirits during the visit.

James Gandolfini -- who famously played Tony Soprano on "The Sopranos" -- died earlier today in Italy ... TMZ has learned.

Gandolfini is believed to have suffered a heart attack. He was 51.

Gandolfini was in Italy to attend the 59th Taormina Film Festival in Sicily -- and he was scheduled to participate in a festival event this weekend with Italian director Gabriele Muccino.

Gandolfini shot to fame playing a hitman in the 1993 hit "True Romance" ... and quickly became a Hollywood legend when he was cast as Tony Soprano in 1999. He won 3 Emmy awards for the role during the show's 6 season run.

'Sopranos' creator David Chase tells TMZ ... "[James] was a genius. He is one of the greatest actors of this or any time. A great deal of that genius resided in those sad eyes. I remember telling him many times, 'You don't get it. You're like Mozart.' There would be silence at the other end of the phone."

Chase added, "He was my partner, he was my brother in ways I can't explain and never will be able to explain.”

Gandolfini also appeared in a ton of huge movies including "Get Shorty," "The Mexican" and "Zero Dark Thirty."

We last spoke to Gandolfini in May in L.A. -- he was in great spirits, making funny faces and joking about a "Sopranos" movie.

His 'Sopranos' co-star Joseph R. Gannascoli -- who played Vito -- tells us, "James is one guy who never turned his back on me. He was the most humble and gifted actor and person I have ever worked with ... and I will forever be indebted to him."

Gandolfini is survived by his wife Deborah Lin, who gave birth to the couple's daughter in October 2012. He also has a teenage son from a previous marriage. R.I.P.

Good news everyone ... James Gandolfini has spelled out the circumstances for a "SOPRANOS" MOVIE!!!!

Bad news ... the plan entails the show creator being extremely irresponsible with the fortune he made from the series.

Gandolfini was leaving Madeo with his wife this weekend -- when we talked mafia ... and we even got a reaction from the guy when we asked how he felt about the infamous "Sopranos" finale.

There may still be some life left in Tony Soprano ... if he wasn't actually whacked in that diner ... at least according to "Sopranos" creator David Chase.

Chase was at an event in NYC last night, when we asked him if Tony, Carmela, Meadow and the rest of the gang will ever appear on the big screen ... even though the HBO series ended in 2007.

Chase replied, "I would never say there was never a chance ... but uh, nobody's working on it."

James Gandolfini tackled the mother of all political debates: Abraham Lincoln or George Washington ... who'd kick whose ass? Let the $1 bill versus $5 bill battle royale begin!

According to the clip, the female crew member on VH1's new restaurant-themed "Famous Food" -- which also stars Heidi Montag, Danielle Staub, and Ashley Dupre -- refused to return Vinnie's car after a long day of shooting, claiming the actor had been drinking a lot ... and Vinnie FLIPPED.

Vinnie denies drinking in the clip -- insisting he poured his wine back into the bucket all night ... but the crew member doesn't budge.

TMZ ran into "Sopranos" star Joseph Gannascoli at Vincent's Restaurant in New York yesterday -- where he admitted that his show "paved the way" for Snooki & company ... who also play Italian stereotypes on TV.

And in a horrible twist of fate ... Jwoww and her reality show crew also showed up to the restaurant.

Borino-Quinn won the role in an open casting call and had no prior acting experience at the time. She lost 175 pounds after the show went off the air using stomach stapling surgery, but was still often recognized by fans.]

The question is ...