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Big break in the Matthew Perry death investigation -- there have been multiple arrests made, including at least one doctor ... TMZ has learned.

Law enforcement sources tell us ... multiple law enforcement agencies have executed search warrants and seized computers, phones and other electronic equipment to determine who supplied Perry with the ketamine that caused him to lose consciousness last October and drown in his hot tub in Pacific Palisades, Los Angeles.

Perry had been getting ketamine infusion therapy for anxiety and depression, but the last therapy was a week and a half before his death, so the ketamine in his system was not doctor-prescribed.

Rock legend Greg Kihn -- the guy behind "Jeopardy" and "The Breakup Song" -- has died after a fight with Alzheimer’s.

The tragic news was shared on his official blog ... revealing he died Tuesday ... with the tribute, "Rest in peace, dear Greg. Your music, your voice, your stories, your spirit and your passion will forever echo in our hearts and inspire countless souls."

Born in Baltimore, Greg made his mark in the SF Bay Area music scene ... really hitting it big in the ’80s with his unique mix of rock, folk, blues and pop with The Greg Kihn Band.

Blake Lively’s dealing with the "It Ends With Us" scandal by putting damage control on ice and turning up the volume on her BFF Taylor Swift's fandom ... 'cause priorities, right?

The actress quipped about her wish for 47-hour-long Tay Tay concerts Wednesday, when a caller on BBC Radio 1’s "Unpopular Opinion" segment suggested cutting "Love Story" from the set list to make room for another lesser-known track from her "Fearless" album.

Blake wasn’t having it ... grilling the caller, asking if they just hated happiness, joy, or even their own ears, with that dry humor of hers ... which hasn't exactly translated well in her past interviews -- but we’ll dive into that tea later.

Luana Alonso's putting claims of inappropriate behavior at the Paris Olympics in her rearview ... 'cause she's back on the 'Gram -- posting spicy bikini snaps.

The Olympic swimmer -- who recently denied claims she was kicked out of the 2024 Olympic Village in Paris -- shared a photo collage Wednesday ... including one snap in a tiny black top.

Another pic showed the Paraguayan bombshell in a more conservative, cowgirl-inspired ensemble ... though she still gave fans a glimpse at her long, tan legs.

Rachael Gunn -- best known by her breakdancing name Raygun -- is addressing the reaction to her viral performance at the Paris Olympics, saying the hate has been "devastating."

The 36-year-old Australian posted a video to her Instagram page on Thursday, commenting on the backlash, and thanking her supporters.

"I really appreciate the positivity, and I’m glad I was able to bring some joy into your lives; that’s what I hoped," Gunn said.

Swifties aren't letting last week's thwarted terror plot in Vienna keep them from seeing Taylor Swift in London ... as thousands of fans have already descended on Wembley Stadium.

Check out the new pics from the scene -- mega-fans have already begun congregating on Olympic Way outside the famed London stadium ... where Taylor is set to perform 5 sold-out nights, her final stop on the European leg of her Eras Tour.

Swifties aren't the only ones showing up in droves -- there is an increased amount of security lined up outside the venue, as well. Though, we're sure some fans are about to be turned away ... as TMZ previously reported, Tay-gating has been outright banned during TS's latest London stop.

A Florida couple was attacked by masked gunmen outside their home after winning a sizable casino jackpot ... and, their home security cam caught the whole scene on video.

Kim Chambliss and her BF Val Delacruz came back from a date night at the Seminole Hard Rock Casino in Tampa, Florida ... when two men ran up to them, guns drawn and demanding money.

Check out the video ... Kim's shot in the calf but was able to slip inside the door, away from danger. Meanwhile, Val lays prone on the doorstep, nursing an injury to one of his legs while the first man comes up to him with a huge pistol in his hand.

Kevin Durant is in the company of some new gold AND some stunning acquaintances ... 'cause the NBA superstar is celebrating his Olympic win surrounded by a ton of attractive women -- and he enlisted his teammate, Devin Booker, for the party!!

TMZ Sports has obtained some pics of the Slim Reaper's post-Paris escapades ... and it's clear he's on Cloud 9 after Team USA handled business and defeated France in the final round on Saturday.

K.D. -- who became the States' all-time leading scorer in international play during the latest run for the Red, White and Blue -- made his way to St. Tropez to keep the vibes high after the big win ... and it's clear he wasn't mad one bit about his surroundings.

Jeff Bezos and Lauren Sanchez might be feeling more blessed than usual today ... 'cause they're fresh off meeting the Pope, and diving into climate change with him.

Lauren shared several photos alongside her soon-to-be husband early Thursday morning ... all featuring Pope Francis in his full regalia, shaking hands with Sanchezos and posing for pics.

Both Sanchez and Bezos dressed in their Sunday best for the meeting, with their black outfits offsetting the Pope's perfectly.

Former NASCAR champion Kurt Busch was arrested on Tuesday night ... after authorities say they caught him driving drunk.

The 46-year-old was pulled over at around 11:30 PM in Iredell County, North Carolina ... following allegations he was driving 18 MPH over the posted 45-MPH speed limit, this according to the Iredell Free Press.

The outlet, citing court documents, reported Busch told officers he had been drinking prior to the stop -- and elicited signs of being wasted, including having "red glassy eyes."

Age is just a number ... because even senior citizens are sliding into DMs with some bold d*** photos -- just ask the new 'Golden Bachelorette,' Joan Vassos.

The 61-year-old spilled the tea about her DMs going off the rails after her run on Gerry Turner's "The Golden Bachelor" ... saying she was also getting straight-up foot fetish offers with cash on the table.

In fact, Joan told Entertainment Weekly one person even offered to buy every pair of shoes she wore on "GB" ... which definitely gave her the chills.

North West's ripping a page out of her mom's pal Paris Hilton's playbook -- walking her little dog around the Big Apple, and accessorizing with it!

TMZ got this video of Kim Kardashian and Kanye West's daughter out for a stroll Wednesday night in NYC on her own -- well, she had security guards -- as she left the luxurious Ritz-Carlton with a tiny furry friend on a leash.

North matched her own furry 'fit to the dog, putting on a coat made of two different kinds of faux fur, it appears -- a look West's mom and aunts have pulled off for years.

Katy Perry has come out with a "Dark Horse" of a defense in her recent music video drama ... with her record label ponying up proof they were given the OK to film in the sensitive sand dunes of a protected area on a Spanish island.

After the Spanish government kicked off a probe this week into KP's decision to film her "Lifetimes" music video on protected ground, Capitol Records hit back with a response ... saying they were given all the necessary permits to record at the dunes of S’Espalmador.

Per a CR rep, there was one permit that was still lingering before production for the music video kicked off ... but they defend they were given verbal approval the day before shooting began on July 27.

Tom Brady, unretiring AGAIN?!

That's what TB12 joked while soakin' up the sun on a yacht off the coast of Italy, firing footballs from the boat ... and proving he's still got the arm to play in the NFL!

The soon-to-be Hall of Famer dropped the 9-minute debut episode of his new vlog, "Last Week with Tom Brady," which is produced by Shadow Lion, where he did everything from watching Simone Biles in person at the Paris Olympics with his daughter Vivian, to hangin' on a beautiful yacht in the Mediterranean with Michael Rubin and others.

At one point in the ep, Rubin, founder of Fanatics, was on a jet ski ... a perfect opportunity for Brady to throw a few passes to his buddy out on the water.

Kim Kardashian says she's content with being single right now, but that hasn't stopped her little kiddos from trying to hook her up with potential suitors.

The reality star sat down Wednesday with host Jimmy Fallon on "The Tonight Show With Jimmy Fallon" for a wide-ranging interview that eventually turned to Kim's love life.

Jimmy was the one who brought up the subject, asking,  What's going on with the love scene? Are you seeing anyone?"

Gena Rowlands, who famously played Allie in "The Notebook," is dead ... TMZ has learned.

The retired actress died Wednesday afternoon at her home in Indian Wells, CA ... where she was surrounded by family, including her husband, Robert, and her daughter Alexandra Cassavetes.

We're told her son, director Nick Cassavetes, had also been at the home frequently this week.