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Leon Edwards' crazy upset win over Kamaru Usman at UFC 278 made Drake's pockets a bit lighter this weekend -- 'cause the rapper lost out on a $200k bet!!

"The Nigerian Nightmare" was handed just his second professional loss after a head-kick knockout in the fifth round ... a result that had the fighting world absolutely shocked.

Drizzy was so confident the fight would end up in Usman's favor, he actually put up nearly a quarter million on an Usman knockout.

Of course, that didn't happen ... so all that dough went down the drain.

Edwards got wind of Champagne Papi's bet ... and made sure to clap back at the rapper in his post-fight interview, telling him to make the right decision next time.

As it turns out, Drake was taking Ls left and right on Saturday ... because he also lost $230k after Jose Aldo lost to Merab Dvalishvili.

It's become a trend for Drake to place massive sports bets ... but it hasn't gone too well for him over the years -- he's lost close to a million bucks on UFC fights alone.

Ben Affleck needs a nap -- at least that much is obvious from these photos of him on the road in Georgia ... where the dude looks absolutely drained post-wedding weekend.

The actor was photographed Sunday night being driven to a private airport, with a police escort in town that had the entryway to the facility blocked off to try and keep fans and photogs away.

Ben looks exhausted, leaning over to his right side with his eyes partially closed.

We're told his bride, Jennifer Lopez, was also in the SUV, but you can't see her in the pics.

It appears Ben and the gang were on their way to a private jet to get 'em outta Savannah -- where they've been for the past several days celebrating his and J Lo's second nuptials ... this time in the presence of friends and family.

Some famous faces flew in for the shindig at BA's estate -- including his bestie, Matt Damon -- but there were some notable absences as well ... including his brother, Casey, and his ex-wife Jennifer Garner. For what it's worth, Marc Anthony also skipped the get-together.

Bennifer enjoyed themselves nonetheless ... decked out in all-white and smooching at every opportunity. It definitely looked like the wedding of a lifetime, from the pics we've seen.

Caleb VanHooser and Christian Eubanks, players for the Indiana State University football team, tragically died in a car accident over the weekend ... according to multiple reports.

"There are no words to express the depth of our sadness about this tragedy," school president Dr. Deborah J. Curtis said. "We send our condolences to the family and friends of the students involved. The Sycamore family is mourning and will support each other in this time of grief."

VanHooser's former school -- Lakota East High School -- confirmed the tragic news of his passing ... writing, "It is with (a) heavy heart that we mourn the loss of Caleb VanHooser, former Hawk great, and Indiana State football player who was called home to Heaven early this morning."

"We will never forget his contributions to our program. RIP #2. We love you."

Officials from Indiana State University also released a statement, saying ... "It is with great sorrow that Indiana State University announces that police are working to positively identify three people who died in a single-vehicle accident early Sunday morning."

The Vigo County Sheriff's Office says the crash happened around 1:34 AM on Sunday, according to WTHR ... when a vehicle traveling on State Road 46 -- not too far from ISU's campus -- veered off the road, struck a tree and caught on fire.

VanHooser and Eubanks were 2 of the 5 people trapped inside the vehicle, which was engulfed in flames by the time first responders arrived, according to the outlet.

VanHooser and Eubanks were freshmen at ISU.

Once the news about VanHooser's death circulated on social media, hundreds of people wearing blue and white gathered at Memorial Stadium to pay their respects.

Dr. Anthony Fauci is set to retire from his position as one of the country's top Docs ... but will see his duties through 'til the end of the year.

The director of the NIAID broke the news Monday with a lengthy statement. He says, in part, "I am announcing today that I will be stepping down from the positions of Director of National Institute of Allergy and Infectious Diseases and Chief of the NIAID Laboratory of Immunoregulation, as well as the position of Chief Medical Advisor to President Joe Biden."

He adds, "I will be leaving these positions in December of this year to pursue the next chapter of my career." It's unclear what Fauci plans to do next.

Fauci goes on to say what an honor it's been to serve in his role for the past 38 years, not to mention his other 15 years of service at the NIAID before he was a honcho. He's graceful in his statement, writing ... "I have worked with -- and learned from -- countless talented and dedicated people in my own laboratory, at NIAID, at NIH and beyond. To them I express my biding respect and gratitude."

Fauci's career is quite storied ... he has served under multiple presidents, including Lyndon Johnson, Gerald Ford, Jimmy Carter, Ronald Reagan, George H.W. Bush, Bill Clinton, Dubya, Barack Obama, Donald Trump and, of course, JB.

Along the way, Dr. Fauci has helped Americans combat major viruses that have plagued society in the 20th and 21st centuries -- including instrumental research and work in regards to the Ebola and Zika viruses ... not to mention the swine flu pandemic, the bird flu scare and other widespread infectious disease occurrences that hit the world over the decades.

His contributions to HIV/AIDS research can't be overstated ... Fauci was in the trenches in the '80s, and he has said much of his work is defined by that period. Dr. Fauci helped develop treatments -- although the rollout and discussion of it all were heavily criticized at the time.

Frankly, he's been a lightning rod for years now ... often bearing the brunt of widespread outrage and condemnation when it comes to the federal government's response to health-related outbreaks. That was, perhaps, most crystalized of late ... during COVID-19 pandemic.

Many will recall ... Fauci was often battling against his own boss, DT, when it came to discussing the coronavirus -- he wanted people to be cautious and get vaccinated, while Trump usually pushed for the opposite ... making for some heated public clashes.

Still, he stayed the course through it all ... and always maintained his composure. Fauci hasn't always been right from the get-go, but he did always pivot when more information surfaced and updated his recommendations as such. That much nobody can deny.

Blueface's girlfriend is in police custody after punching him square in the face -- the second time in less than a month -- but he's begging cops to let her go free.

Chrisean Rock unloaded on the rapper Sunday night while they were in Whiskey Row bar in Scottsdale, AZ. Blueface was standing in front of Chrisean when she hauled back and struck him twice in the face.

She landed both shots, sending Blueface backward and he made no attempt to go back at her. Instead, security took her down ... pinning Chrisean to the ground until Scottsdale PD arrived to haul her off in handcuffs.

So, Blueface's reaction to the violent incident? "Free Rock!!!"

He posted a video saying, "We don't ever make the same mistake twice" ... clearly referring to their very public fight earlier this month.

TMZ broke the story when they both went at each other on the streets of Hollywood -- Chrisean threw the first punch, but Blueface, who's slated to box Nick Young in a celeb event next month, fought back, pinning her to the ground. Cops didn't witness the fight, but after seeing video said they'd opened an investigation.

Nothing's come of that incident yet, and the couple never broke up over it, but now -- with Chrisean in jail -- Blueface says he wants her freed, we think. He was kinda laughing during the video.

One thing he didn't laugh about was the punch, as he put it ... "She hit me with a banger. I was like, oooh!!!"

Scott Disick was involved in a car accident this weekend -- but it sounds like he's going to be okay ... TMZ has learned.

Law enforcement sources tell us ... the reality star had his car dinged up Sunday while driving near Calabasas. Unclear where exactly this might've occurred out there, but we're told Scott's Lamborghini SUV rolled over in the wreck ... one that only involved his vehicle, and luckily not any others. We're told he was alone in the car, and didn't appear impaired.

Our sources say SD sustained a minor cut to his head, and that when paramedics arrived ... he refused medical attention. So it seems he wasn't seriously injured.

Again ... we're not entirely sure on what possibly made Scott's car to flip like this, but we are told that speed appears to have been a factor, based on a preliminary investigation by cops. Scott's Lambo was towed from the scene ... he was not cited in the end.

Scott has been out and about all over L.A. these past few days -- including an outing at Nobu with a mystery woman earlier in the week ... as well as another dinner at Giorgio Baldi on Saturday night, alongside none other than Rod Stewart's daughter, Kimberly.

Him hitting the town seems to jibe with what Kourtney was up to on Sunday -- she posted a photo of her and their son, Reign, hanging out in a pool. So it seems she's got the kids this weekend.

Scott and Kourtney continue to co-parent their three little ones -- this as KK has gone on to marry Travis Barker this year ... a relationship that SD, at times, has apparently bristled over.

We've reached out to his reps for further comment ... so far, no word back.

Tyson Fury says his cousin was killed after being stabbed in the neck in the UK over the weekend ... and now, he's pleading with government officials to crack down on knife crime in wake of the tragedy.

According to authorities, Fury's relative, 31-year-old Rico Burton, was killed following an incident at a popular bar at around 3 AM on Sunday in Manchester. A 17-year-old was also injured in the altercation, cops said, and remains hospitalized.

Fury took to his Instagram page after learning of Burton's death to mourn the loss -- and called for greater punishment for knife crimes to hopefully deter similar incidents from happening going forward.

"This is becoming ridiculous," the boxing superstar said. "Idiots carry knives. This needs to stop 🛑 Asap, uk 🇬🇧 government needs to bring higher sentencing for knife crime, its a pandemic & you dont know how bad it is until its 1 of your own!"

He added, "Life is very precious & it can be taken away very quick enjoy every moment🙏RIP RICO BURTON 🙏 may the lord god grant you a good place in heven. see you soon"

Police say they have arrested two men who they believe were involved in the stabbing. They added that they are increasing police patrols in the area with the hopes of preventing future crimes.

"This was a senseless attack," Greater Manchester Police spokesperson Ben Ewart said, "and both victims should've returned home this morning after enjoying a night out with friends."

Three Arkansas sheriff's deputies have been benched after a video shows them wailing on a homeless man with alleged mental health issues.

The Crawford County Sheriff's Department confirms two of the men in uniform seen are their own deputies, and a third officer belongs to the Mulberry Police Dept. They were all teaming up Sunday on a young man -- kneeing him, slamming his head on the concrete and punching him in the face in order to restrain the man.

The brutal beating happened outside Kountry Xpress gas station, where the cops responded to a call for threats made to one of the clerks inside ... allegedly made by the man getting detained. Reports say the man was cooperative at first, but then things went south.

One report says the man allegedly tried to attack an officer, which is what apparently led to the beatdown. Regardless of what happened in the lead-up, the force shown by the officers is extreme.

At one point, the officers notice they're being filmed, and yell at bystanders to get lost. The Arkansas State Police is currently investigating.

Aqib Talib won't be broadcasting NFL games for Amazon after all -- at least not for the foreseeable future -- he's stepping away from the gig following his brother's murder charge.

NFL Network insider Ian Rapoport reported the news late Sunday evening ... saying after Talib and his older brother, Yaqub Talib, were involved in an altercation at a youth football game earlier this month where a man died, Aqib is now prioritizing time with his family instead of work.

As we previously reported, the Talib brothers were helping coach kids at a football game in Texas on Aug. 13 when an argument between coaches and refs turned deadly.

According to a witness on the field, Aqib was upset with a penalty call and ran onto the playing surface to confront refs. A short time later, a scuffle broke out.

Video, obtained by TMZ Sports, shows a man who appeared to be wielding a down marker to hit others was eventually shot. Authorities say he was transported to a local hospital, but died there due to his injuries.

Cops have accused Yaqub of pulling the trigger ... and the 39-year-old has since been charged with murder.

36-year-old Aqib, meanwhile has not been charged with any crimes.

"Aqib was present when this unfortunate incident occurred and is very distraught and devastated over this terrible loss of life," Aqib's attorney said following the incident. "He would like to convey his condolences to the family of the victim and to everyone who witnessed this unfortunate tragedy."

Even politicians have to get away every once in a while ... and Vice President Kamala Harris took advantage of her Hawaiian vacay by going on a hike -- with protection right behind her, of course.

Eyewitnesses tell TMZ ... the VP hit up Haena State Park last week on the island of Kauai -- all smiles as she walked down the narrow trail, wearing an outfit that screams, vacation mode!

She was leading the charge of about 20 others ... some of whom were Secret Service, dressed down as they shadowed her. We're told the Veep was in good spirits during her time on the trail.

Air Force 2 reportedly touched down at the Lihue Airport Monday ... sources told Hawaii News Now her unannounced trip is for pleasure, not business -- she's supposed to be on the island for a week or so.

Former AEW star Jake Atlas told cops he was "an international trained superstar" and then slammed his boyfriend as "terrible at sex" in a rant during his arrest back in May ... new police video shows.

In the footage, obtained by TMZ Sports, you can see a police officer was trying to ask an agitated Atlas questions about an alleged domestic violence incident between him and his BF outside of his Orlando, Fl. home on May 23.

But, the wrestler, whose boyfriend had accused him of roughing him up during an argument earlier in the evening, appeared to be in no mood to play ball with the cop.

Instead, Atlas told the officer about his wrestling resume, all while bashing his boyfriend and their relationship repeatedly.

"I am an international trained superstar," said the 27-year-old, who is openly gay. "I have worked across the country, across the world, with my name. He is a nobody."

Atlas, real name Kenny Sanchez Martinez, went on to call the man a "f**ing bitch ass, f***ing p***y" ... before ultimately telling the cop, "[he] is a terrible boyfriend and he's terrible at sex."

The cop tried repeatedly to get Atlas to tell his side of the story and explain the events that had gone down earlier in the evening, but the wrestler never seemed to cooperate. Atlas was eventually arrested on the scene and later booked on a domestic violence battery charge.

Atlas' charges were eventually dropped, however ... with officials writing in court documents, "this case is not suitable for prosecution."

The wrestler later commented on the case following its disposition in July, apologizing "for my wrongdoing and any hurt, disappointment and complication I may have caused to my colleagues and fans."

Atlas said he participated in an outpatient program to deal with "a dual diagnosis in substance abuse and mental health," and is continuing to seek treatment.

"Black Ink Crew" member Richard "O'S***" Duncan must have been thinking, "Oh, s***" after getting pulled over by the police ... because the traffic stop resulted in his arrest.

The former reality TV star was busted for DUI in July after cops in Georgia say they stopped him for speeding.

According to the incident report, obtained by TMZ, Richard was pulled over for speeding. Cops say they smelled alcohol and did a field sobriety test.

Police say Richard admitted he had been drinking. During a search of his car, cops say they found a bag of cocaine in the center cupholder.

He was charged with speeding, DUI, driving with an open container of alcohol and possession of a controlled substance. The possession charge is a felony and the rest are misdemeanors. He has pled not guilty.

Richard has battled alcohol and substance abuse problems over the years ... even being put on professional leave to deal with his issues during the first season of the VH1 reality show. Now, he owns Drip Tattoo Collective in Atlanta.

Before this cutie pie turned into a home cleaning expert and an accomplished actress, she was just a little girl with big dreams and high hopes of being a famous performer while growing up in Missouri and Southern California.

This kiddo made her acting debut in the 1995 film "Boys On The Side" alongside Whoopi Goldberg, Drew Barrymore and Matthew McConaughey and worked her way to earning a star on The Hollywood Walk of Fame in 2018.

Need one more clue on who this unapologetic pioneer is? Just ask her musician wife Jessica Betts.

Marc Anthony was looking pretty chipper this weekend -- waving to dock workers and flashing a big grin ... this amid missing his ex-wife's second wedding with Ben Affleck.

The Latin superstar was seen throwing up salute gestures to guys working out in a marina down in Miami -- where MA's apparently got a boat of his stationed -- and as he was being escorted to a waiting sprinter van to whisk him away ... he was in a greeting mood.

Of course, he's a ways from Georgia ... where his Jennifer Lopez was saying "I do" with her new hubby with friends and family around. But that bunch obviously didn't include Marc.

The massive shindig also didn't see Ben's own ex-wife, Jennifer Garner, in attendance -- although she was sort of in their neck of the woods ... popping up at a Sam's Club in her native West Virginia Saturday just as all the festivities for Bennifer were getting underway.

In addition to both Ben and Jen's famous exes not showing face for their nuptials ... Ben's own brother, Casey Affleck also skipped it, opting to stay in L.A. and pound Starbucks instead of flying out to Savannah to by his only sibling's side.

NBD that neither of their former longtime SOs made it out to party. Frankly, it probably be a little weird ... and it seems that in this very modern blended family, co-parenting is #1 -- so if it's not directly tied to the kids, there might be little to no reason to mingle.

All good ... Ben and Jen had a ball anyway, and their wedding certainly looked like one to remember.

Congrats!

A famous search and rescue dive team that inserted itself into the hunt for missing teenager, Kiely Rodni, claims they've found her ... but it doesn't sound like she's alive.

The YouTubers known as Adventures with Purpose -- which has millions of subscribers and followers across their social media channels -- made the claim Sunday, writing on their official Facebook page ... "WE JUST FOUND KIELY RODNI."

They go on to say that she is confirmed to be inside a vehicle that is upside down in about 14 feet of water, adding that the family has been notified and that law enforcement is on their way. As for where exactly they discovered her ... reports suggest it might be in Prosser Lake.

This is where Kiely first went missing weeks ago at the beginning of the month, and the search efforts thus far have been focused on this area. AWP literally just volunteered their service a day or two ago ... vowing to help locate her, and it appears they did just that.

As we reported ... Dog the Bounty Hunter told us he'd been getting tons of tips on her potential whereabouts, but was reluctant to jump into the high-profile missing persons case because of all the blowback he got from the Gabby Petito case.

Kiely went missing on Aug. 6 near Truckee, CA -- where she and a bunch of other youths were partying in the Lake Tahoe region.

She went missing late in the night, apparently without a trace ... and hasn't surfaced since. A massive undertaking has been underway to find her.

No other details have come to light yet as to how Kiely may have ended up in a car and submerged in the lake -- and if foul play is suspected.

Tom Brady was apparently all set to become a Raider after leaving the Patriots -- that is, until Jon Gruden stepped in and shot it down ... this according to Dana White.

The UFC honcho broke down the story Saturday during the UFC 278 broadcast ... telling Rob Gronkowski and a bunch of other panelists that TB12 was, in fact, gunning to join the Las Vegas Raiders ... something DW had been pitching him on for a long time at that point.

This was all happening during Tom's free agency period in 2020, BTW, and per Dana ... the GOAT was actually already scoping out houses in the area. So it sounds like it was just about a done deal -- with Dana working behind the scenes to make it all happen.

Not just that ... but Rob himself was apparently going to join Tom there in Vegas under this would-be move. The reason it fell apart, so says Dana, is because of the ex-head coach.

Gruden allegedly blew it up last minute, saying he didn't want Tom and co. -- and, apparently, the ownership listened to him. Tom ended up joining the Bucs instead, and went on to win the Super Bowl later in 2021 ... with none other than Gronk by his side for the glory.

Dana later elaborated a bit on the tale, telling reporters Brady wasn't happy about it at the time ... but wouldn't get into the exact details of what Gruden's beef was.

Of course, he ended up getting canned by the organization amid a racism controversy from prior emails.

Gruden ended up suing the league and NFL commissioner Roger Goodell, claiming the leaked correspondence was part of a coordinated character assassination.