LeSean McCoy -- SHAKES MIKE VICK ... With Killer Crossover

Now, Mike Vick knows how all those defenders felt ...

The NFL quarterback got crossed over HARD at his celebrity basketball game in Virginia this week ... and was left swingin' at air ... and the culprit is one of his closest friends -- LeSean McCoy!

The two former Philadelphia Eagles teammates hit the hardwood at Warwick High School in Newport News -- where Vick grew up -- to raise money for the Mike Vick Foundation, which works with underprivileged kids.

We're told Vick beat McCoy in a 40-yard dash a few years ago ... and McCoy had vowed revenge ... which he finally got on the court.