'Powerpuff Girls' Star – Opens A Can Of Whoop Ass On Cartoon Reboot

"Powerpuff Girls" fans – E.G. Daily, the original voice of Buttercup, is dropping some serious Chemical X on the series reboot … because she’s pissed she didn’t get an invite back.

Townsville’s little superheroes are returning to TV in 2016 ... but the squeaky voices of Bubbles, Buttercup and Blossom will be handled by different actors, despite the rest of the original cast returning.

Our photog got Daily (Buttercup) in L.A., and she did not hold back on the diss ... dropping analogies and tapping into her tough, little green character.

Sugar, spice … everything not so nice …