George Clooney and Stacy Keibler Split -- IT'S OVER!!

It was only a matter of time ... but Stacy Keibler's run with George Clooney is officially done.

Sources close to the couple tell TMZ ... the two have broken up after two years of dating.

The couple hasn't been seen together since March and spent the 4th of July on opposite ends of the earth.

Keibler joins a long list of Clooney exes ... which includes Elisabetta Canalis, Kelly Preston, Talia Balsam, Denise Crosby, Celine Balitran, Brooke Langton, Traylor Howard, Lisa Snowdon and Sarah Larson.

In the meantime, here's a clip of Stacy dancing shaking in almost nothing.

Yeah, she's gonna be just fine ...