49ers Star Chris Culliver -- Trouble Over NEW Offensive Comments

Cue up another round of apologies for Chris Culliver ... 'cause the SF 49ers player is in trouble again over a new set of offensive comments ... but this time, he went after women ... not gays.

Culliver -- the guy who went to sensitivity training after bashing gays right before the Super Bowl -- posted a screen grab of an iPhone conversation to Instagram last night ... in which he and some friends refer to women as "bitches" and "hoes."

Here's the convo:

Culliver's friend: This bitch talkin bout how I can take her on a nice dat ... yeah my car ... bitch you got a whole dude ... live in work you trippin.

Culliver: Lol yeah hoes be thinking more then they are. Boy I tell you

Culliver's friend: Right these hoes be trippin

The 49ers have released a statement saying "We are aware of the matter, and it is being handled internally."