Dwyane Wade's Ex-Wife -- He's Being a HUGE Pain in the Asthma

Lil Wayne's not the only one who's got beef with Dwyane Wade ... the Miami Heat star's also made an enemy of his ex-wife -- who's now accusing the basketball star of depriving their children of life-saving asthma medication.

Siohvaughn Wade just filed docs in their ongoing custody dispute, claiming Dwyane "has never obtained any asthma inhalers or asthma nebulizer machines for the children since [Dwyane] was awarded children in his custody on March 11, 2011."

Siohvaughn says the ex-couple's two kids both suffer from the condition and require constant supervision.

But according to the docs, "[Dwyane] recklessly failed to provide the five and ten-year-old children with any medication for a life-threatening illness."

Siohvaughn says Dwyane is putting their kids' lives in danger as a result -- and now, she wants a court to ORDER him to be more attentive ... as well as keep her apprised of the kids' medical treatment.

But it doesn't end there -- Siohvaughn also claims Dwyane's been screwing her out of parenting time ... "continuously and willfully making every effort to alienate the children from [her]."

She wants Dwyane prosecuted for visitation abuse.