Mike Tyson to Beat Up Charlie Sheen ... on Comedy Central Roast

Cocaine ... hangovers ... and mug shots -- Mike Tyson and Charlie Sheen are a match made in Comedy Central Roast heaven ... and TMZ has learned Iron Mike is officially on board to skewer the Warlock next month.

Sources heavily involved with the Roast tell us ... Mike will be on the dais on September 10 ... along with Steve-O from "Jackass" ... comic Anthony Jeselnik and Roast legend Jeff Ross.