Mo'Nique Blasts Oprah, Lee Daniels and Tyler Perry ... 'Suck My D***!'

Oscar winner Mo'Nique went NUCLEAR on Lee Daniels, Tyler Perry and Oprah ... blaming the trio for her getting shut out of Hollywood -- in not so many words.

The comedian did a standup special Saturday night at the Apollo Theater, and went off about getting blackballed. She insisted that's the wrong term to use. She prefers ... "whiteballed" ... "by some n*****s who had no balls."

Mo'Nique had a falling out with "Precious" director Lee Daniels after she won the Oscar for that movie, and she's made the 'blackballed in Hollywood' claim before. But this is the first time she's lumped in Oprah and Tyler.

She's also never said it this viciously -- "Y'all can suck my d***, if I had one!"