Robin Thicke -- Cancels Concert ... Cherokees Get Screwed Again

Robin Thicke just backed out on the Cherokee Indians -- canceling his concert at a casino in North Carolina on the heels of his separation from Paula Patton.

Harrah's Cherokee Casino Resort announced Monday night that his Tuesday night show was being postponed "due to unforeseen circumstances" ... aka ... dude's got trouble on the home front.

This makes three straight concerts Thicke has canceled. As we previously reported ... he pulled the plug on shows Friday and Saturday last week -- purportedly for vocal problems -- but it's clear now he was most likely dealing with his marriage.