ABC Interested in Rob Lowe as Regis' Replacement on 'Live' With Kelly Ripa

Rob Lowe could be Regis Philbin's replacement ... if ABC has its way.

Lowe just finished a two-day stint, guest hosting with Kelly Ripa and an ABC source says the honchos "loved the chemistry between them." We're told network execs have spoken with Lowe's reps about making it a permanent gig, but Lowe -- who already has a job on "Parks and Recreation" -- is non-committal.

But we just shot Rob leaving NYC at JFK airport. Our camera guy asked him, "Do you think you could live in New York?"

Rob replied: "We were just talking about that. I love New York. I love the energy. It would be a change of pace. I'm a California boy, but it could be fun."